Unlocking the power and potential of the human immune system to battle cancer, heart disease and other ailments takes imagination, determination and collaboration.
The Immunology Center of Georgia is a new research enterprise that pioneers ways for the body to marshal its immune defenders and attackers to defeat threats to human health.
In partnership with the best clinicians and scientists around the world, we’re working to advance exploration, uncover knowledge and prepare the next generation of immunologists – all to benefit people everywhere.
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A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivoWang, L., He, X., Hu, G., Liu, J., Kang, X., Yu, L., Dong, K., Zhao, J., Zhang, A., Zhang, W., Brands, M. W., Su, H., Zheng, Z. & Zhou, J., Apr 2024, In:Physiological reports. 12, 8, e16014.Research output:Contribution to journal›Article›peer-review |
Identification of apolipoprotein B–reactive CDR3 motifs allows tracking of atherosclerosis-related memory CD4+T cells in multiple donorsRoy, P., Suthahar, S. S. A., Makings, J. & Ley, K., 2024, In:Frontiers in immunology. 15, 1302031.Research output:Contribution to journal›Article›peer-review |
Immunotherapy for atherosclerosis by targeting pro-inflammatory T cellsKhan, A. & Ley, K., Jul 2024, In:Cell Research. 34, 7, p. 467-468 2 p.Research output:Contribution to journal›Article›peer-review |
Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunitiesStroope, C., Nettersheim, F. S., Coon, B., Finney, A. C., Schwartz, M. A., Ley, K., Rom, O. & Yurdagul, A., Apr 2024, In:Nature Metabolism. 6, 4, p. 617-638 22 p.Research output:Contribution to journal›Review article›peer-review |
Blockade of endothelial adenosine receptor 2A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transitionCai, Y., Zhou, Y., Yang, Q., Xu, J., Da, Q., Ma, Q., Zhao, D., Lu, T., Kim, H. W., Fulton, D., Jiang, X., Weintraub, N. L., Dong, K., Xu, S., Hong, M., Liu, Z. & Huo, Y., Mar 22 2024, (E-pub ahead of print) In:Pharmacological Research. p. 107156Research output:Contribution to journal›Article›peer-review |
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in miceKarunakaran, D., Turner, A. W., Duchez, A. C., Soubeyrand, S., Rasheed, A., Smyth, D., Cook, D. P., Nikpay, M., Kandiah, J. W., Pan, C., Geoffrion, M., Lee, R., Boytard, L., Wyatt, H., Nguyen, M. A., Lau, P., Laakso, M., Ramkhelawon, B., Alvarez, M. & Pietiläinen, K. H. & 10 others, , Oct 1 2020, In:Nature Metabolism. 2, 10, p. 1113-1125 13 p.Research output:Contribution to journal›Article›peer-review |
Revisiting the Evidence for Dipyridamole in Reducing Restenosis: A Systematic Review and Meta-analysisSimard, T., Motazedian, P., Dhaliwal, S., Di Santo, P., Jung, R. G., Ramirez, F. D., Labinaz, A., Short, S., Parlow, S., Joseph, J., Rasheed, A., Rockley, M., Marbach, J., Domecq, M. C., Russo, J. J., Chong, A. Y., Beanlands, R. S. & Hibbert, B., Apr 11 2021, In:Journal of Cardiovascular Pharmacology. 77, 4, p. 450-457 8 p.Research output:Contribution to journal›Review article›peer-review |
Macrophage Responses to Environmental Stimuli during Homeostasis and DiseaseRasheed, A.& Rayner, K. J., Aug 1 2021, In:Endocrine Reviews. 42, 4, p. 407-435 29 p.Research output:Contribution to journal›Review article›peer-review |
The secretome of liver X receptor agonist-treated early outgrowth cells decreases atherosclerosis in Ldlr−/− miceRasheed, A., Shawky, S. A., Tsai, R., Jung, R. G., Simard, T., Saikali, M. F., Hibbert, B., Rayner, K. J. & Cummins, C. L., Mar 2021, In:Stem Cells Translational Medicine. 10, 3, p. 479-491 13 p.Research output:Contribution to journal›Article›peer-review |
Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice (Nature Metabolism, (2020), 2, 10, (1113-1125), 10.1038/s42255-020-00279-2)Karunakaran, D., Turner, A. W., Duchez, A. C., Soubeyrand, S., Rasheed, A., Smyth, D., Cook, D. P., Nikpay, M., Kandiah, J. W., Pan, C., Geoffrion, M., Lee, R., Boytard, L., Wyatt, H., Nguyen, M. A., Lau, P., Laakso, M., Ramkhelawon, B., Alvarez, M. & Pietiläinen, K. H. & 10 others, , Oct 1 2020, In:Nature Metabolism. 2, 10, p. 1181 1 p.Research output:Contribution to journal›Comment/debate›peer-review |
Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetesHazra, S., Rasheed, A., Bhatwadekar, A., Wang, X., Shaw, L. C., Patel, M., Caballero, S., Magomedova, L., Solis, N., Yan, Y., Wang, W., Thinschmidt, J. S., Verma, A., Li, Q., Levi, M., Cummins, C. L. & Grant, M. B., Dec 2012, In:Diabetes. 61, 12, p. 3270-3279 10 p.Research output:Contribution to journal›Article›peer-review |
Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in micePatel, M., Wang, X. X., Magomedova, L., John, R., Rasheed, A., Santamaria, H., Wang, W., Tsai, R., Qiu, L., Orellana, A., Advani, A., Levi, M. & Cummins, C. L., Feb 2014, In:Diabetologia. 57, 2, p. 435-446 12 p.Research output:Contribution to journal›Article›peer-review |
Beyond the foam cell: The role of LXRs in preventing atherogenesisRasheed, A.& Cummins, C. L., Aug 7 2018, In:International journal of molecular sciences. 19, 8, 2307.Research output:Contribution to journal›Review article›peer-review |
Loss of the Liver X receptors disrupts the balance of hematopoietic populations, with detrimental effects on endothelial progenitor cellsRasheed, A., Tsai, R. & Cummins, C. L., May 15 2018, In:Journal of the American Heart Association. 7, 10, e007787.Research output:Contribution to journal›Article›peer-review |
Immune profiling and tracking of two-dimensional transition metal dichalcogenides in cells and tissuesGazzi, A., Fusco, L., Orecchioni, M., Keshavan, S., Shin, Y., Grivel, J. C., Rinchai, D., Ahmed, E. I., Elhanani, O., Furesi, G., Rauner, M., Keren, L., Ley, K., Casiraghi, C., Bedognetti, D., Fadeel, B. & Delogu, L. G., Feb 2024, In:Nano Today. 54, 102084.Research output:Contribution to journal›Article›peer-review |
Single Cell High Dimensional Analysis of Human Peripheral Blood Mononuclear Cells Reveals Unique Intermediate Monocyte Subsets Associated with Sex Differences in Coronary Artery DiseaseChatterjee, N., Komaravolu, R. K., Durant, C. P., Wu, R., McSkimming, C., Drago, F., Kumar, S., Valentin-Guillama, G., Miller, Y. I., McNamara, C. A., Ley, K., Taylor, A., Alimadadi, A. & Hedrick, C. C., Mar 2024, In:International journal of molecular sciences. 25, 5, 2894.Research output:Contribution to journal›Article›peer-review |
NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosisKaufmann, B., Leszczynska, A., Reca, A., Booshehri, L. M., Onyuru, J., Tan, Z. H., Wree, A., Friess, H., Hartmann, D., Papouchado, B., Broderick, L., Hoffman, H. M., Croker, B. A., Zhu, Y. P.& Feldstein, A. E., Jan 1 2024, In:EMBO Reports. 25, 1, p. 455 1 p.Research output:Contribution to journal›Article›peer-review |
Examining the interplay between cardiovascular disease and cancer incidence: Data from NHANES III and continuousMakram, O. M., Kunhiraman, H. H., Harris, R. A., Hedrick, C. C., Nasir, K., Weintraub, N. L., Wang, X. & Guha, A., Apr 2024, In:American Heart Journal Plus: Cardiology Research and Practice. 40, 100380.Research output:Contribution to journal›Article›peer-review |
NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophilsZhu, Y. P., Speir, M., Tan, Z. H., Lee, J. C., Nowell, C. J., Chen, A. A., Amatullah, H., Salinger, A. J., Huang, C. J., Wu, G., Peng, W., Askari, K., Griffis, E., Ghassemian, M., Santini, J., Gerlic, M., Kiosses, W. B., Catz, S. D., Hoffman, H. M. & Greco, K. F. & 6 others, , Dec 2023, In:Science Advances. 9, 51, eadj1397.Research output:Contribution to journal›Article›peer-review |
Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapyKaczanowska, S., Murty, T., Alimadadi, A., Contreras, C. F., Duault, C., Subrahmanyam, P. B., Reynolds, W., Gutierrez, N. A., Baskar, R., Wu, C. J., Michor, F., Altreuter, J., Liu, Y., Jhaveri, A., Duong, V., Anbunathan, H., Ong, C., Zhang, H., Moravec, R. & Yu, J. & 24 others, , Jan 8 2024, In:Cancer Cell. 42, 1, p. 35-51.e8Research output:Contribution to journal›Article›peer-review |
Editorial: Role of innate and adaptive immune cells in the metabolic syndromeRoy, P., Winkels, H., Orecchioni, M., Quesada-Masachs, E. & Riffelmacher, T., 2024, In:Frontiers in Cell and Developmental Biology. 12, 1383642.Research output:Contribution to journal›Editorial›peer-review |
Breaking tolerance: the autoimmune aspect of atherosclerosisKhan, A., Roy, P. & Ley, K., Sep 2024, In:Nature Reviews Immunology. 24, 9, p. 670-679 10 p.Research output:Contribution to journal›Article›peer-review |
Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality.Rasheed, A., May 13 2015, In:The Journal of biological chemistry.Research output:Contribution to journal›Article›peer-review |
Delivery of MicroRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux in Vitro and in Vivo.Rasheed, A., Jun 12 2019, In:ACS Nano.Research output:Contribution to journal›Article›peer-review |
RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in MiceKarunakaran, D., Nguyen, M.-A., Geoffrion, M., Vreeken, D., Lister, Z., Cheng, H. S., Otte, N., Essebier, P., Wyatt, H., Kandiah, J. W., Jung, R., Alenghat, F. J., Mompeon, A., Lee, R., Pan, C., Gordon, E., Rasheed, A., Lusis, A. J., Liu, P. & Matic, L. P. & 7 others, , 2021, In:Circulation.Research output:Contribution to journal›Article›peer-review |
The secretome of liver X receptor agonist treated early outgrowth cells decreases atherosclerosis in Ldlr-/- MiceRasheed, A., Shawky, S., Tsai, R., Jung, R. G., Simard, T., Hibbert, B., Rayner, K. J. & Cummins, C. L., 2019Research output:Other contribution |
Loss of MLKL (Mixed Lineage Kinase Domain-Like Protein) Decreases Necrotic Core but Increases Macrophage Lipid Accumulation in Atherosclerosis.Rasheed, A., Mar 26 2020, In:Arteriosclerosis, thrombosis, and vascular biology.Research output:Contribution to journal›Article›peer-review |
Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells during AtherosclerosisRobichaud, S., Rasheed, A., Pietrangelo, A., Doyoung Kim, A., Boucher, D. M., Emerton, C., Vijithakumar, V., Gharibeh, L., Fairman, G., Mak, E., Nguyen, M. A., Geoffrion, M., Wirka, R., Rayner, K. J. & Ouimet, M., Mar 18 2022, In:Circulation research. 130, 6, p. 831-847 17 p.Research output:Contribution to journal›Article›peer-review |
The scent of atherosclerosisRayner, K. J. & Rasheed, A., Jan 14 2022, In:Science. 375, 6577, p. 145-146 2 p.Research output:Contribution to journal›Short survey›peer-review |
Dipyridamole and vascular healing following stent implantationSimard, T., Jung, R., Di Santo, P., Labinaz, A., Short, S., Motazedian, P., Dhaliwal, S., Sarma, D., Rasheed, A., Ramirez, F. D., Froeschl, M., Labinaz, M., Holmes, D. R., Alkhouli, M. & Hibbert, B., 2023, In:Frontiers in Cardiovascular Medicine. 10, p. 1130304Research output:Contribution to journal›Article›peer-review |