Immunology Research

Unlocking the power and potential of the human immune system to battle cancer, heart disease and other ailments takes imagination, determination and collaboration.

The Immunology Center of Georgia is a new research enterprise that pioneers ways for the body to marshal its immune defenders and attackers to defeat threats to human health.

In partnership with the best clinicians and scientists around the world, we’re working to advance exploration, uncover knowledge and prepare the next generation of immunologists – all to benefit people everywhere.

Publication
A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo Wang, L., He, X., Hu, G., Liu, J., Kang, X., Yu, L., Dong, K., Zhao, J., Zhang, A., Zhang, W., Brands, M. W., Su, H., Zheng, Z. & Zhou, J., Apr 2024, In: Physiological reports. 12, 8, e16014. Research output: Contribution to journal › Article › peer-review
Identification of apolipoprotein B–reactive CDR3 motifs allows tracking of atherosclerosis-related memory CD4⁺T cells in multiple donors Roy, P., Suthahar, S. S. A., Makings, J. & Ley, K., 2024, In: Frontiers in immunology. 15, 1302031. Research output: Contribution to journal › Article › peer-review
Immunotherapy for atherosclerosis by targeting pro-inflammatory T cells Khan, A. & Ley, K., Jul 2024, In: Cell Research. 34, 7, p. 467-468 2 p. Research output: Contribution to journal › Article › peer-review
Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities Stroope, C., Nettersheim, F. S., Coon, B., Finney, A. C., Schwartz, M. A., Ley, K., Rom, O. & Yurdagul, A., Apr 2024, In: Nature Metabolism. 6, 4, p. 617-638 22 p. Research output: Contribution to journal › Review article › peer-review
Blockade of endothelial adenosine receptor 2A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition Cai, Y., Zhou, Y., Yang, Q., Xu, J., Da, Q., Ma, Q., Zhao, D., Lu, T., Kim, H. W., Fulton, D., Jiang, X., Weintraub, N. L., Dong, K., Xu, S., Hong, M., Liu, Z. & Huo, Y., Mar 22 2024, (E-pub ahead of print) In: Pharmacological Research. p. 107156 Research output: Contribution to journal › Article › peer-review
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice Karunakaran, D., Turner, A. W., Duchez, A. C., Soubeyrand, S., Rasheed, A., Smyth, D., Cook, D. P., Nikpay, M., Kandiah, J. W., Pan, C., Geoffrion, M., Lee, R., Boytard, L., Wyatt, H., Nguyen, M. A., Lau, P., Laakso, M., Ramkhelawon, B., Alvarez, M. & Pietiläinen, K. H. & 10 others, Pajukanta, P., Vanderhyden, B. C., Liu, P., Berger, S. B., Gough, P. J., Bertin, J., Harper, M. E., Lusis, A. J., McPherson, R. & Rayner, K. J., Oct 1 2020, In: Nature Metabolism. 2, 10, p. 1113-1125 13 p. Research output: Contribution to journal › Article › peer-review
Revisiting the Evidence for Dipyridamole in Reducing Restenosis: A Systematic Review and Meta-analysis Simard, T., Motazedian, P., Dhaliwal, S., Di Santo, P., Jung, R. G., Ramirez, F. D., Labinaz, A., Short, S., Parlow, S., Joseph, J., Rasheed, A., Rockley, M., Marbach, J., Domecq, M. C., Russo, J. J., Chong, A. Y., Beanlands, R. S. & Hibbert, B., Apr 11 2021, In: Journal of Cardiovascular Pharmacology. 77, 4, p. 450-457 8 p. Research output: Contribution to journal › Review article › peer-review
Macrophage Responses to Environmental Stimuli during Homeostasis and Disease Rasheed, A. & Rayner, K. J., Aug 1 2021, In: Endocrine Reviews. 42, 4, p. 407-435 29 p. Research output: Contribution to journal › Review article › peer-review
The secretome of liver X receptor agonist-treated early outgrowth cells decreases atherosclerosis in Ldlr−/− mice Rasheed, A., Shawky, S. A., Tsai, R., Jung, R. G., Simard, T., Saikali, M. F., Hibbert, B., Rayner, K. J. & Cummins, C. L., Mar 2021, In: Stem Cells Translational Medicine. 10, 3, p. 479-491 13 p. Research output: Contribution to journal › Article › peer-review
Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice (Nature Metabolism, (2020), 2, 10, (1113-1125), 10.1038/s42255-020-00279-2) Karunakaran, D., Turner, A. W., Duchez, A. C., Soubeyrand, S., Rasheed, A., Smyth, D., Cook, D. P., Nikpay, M., Kandiah, J. W., Pan, C., Geoffrion, M., Lee, R., Boytard, L., Wyatt, H., Nguyen, M. A., Lau, P., Laakso, M., Ramkhelawon, B., Alvarez, M. & Pietiläinen, K. H. & 10 others, Pajukanta, P., Vanderhyden, B. C., Liu, P., Berger, S. B., Gough, P. J., Bertin, J., Harper, M. E., Lusis, A. J., McPherson, R. & Rayner, K. J., Oct 1 2020, In: Nature Metabolism. 2, 10, p. 1181 1 p. Research output: Contribution to journal › Comment/debate › peer-review
Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes Hazra, S., Rasheed, A., Bhatwadekar, A., Wang, X., Shaw, L. C., Patel, M., Caballero, S., Magomedova, L., Solis, N., Yan, Y., Wang, W., Thinschmidt, J. S., Verma, A., Li, Q., Levi, M., Cummins, C. L. & Grant, M. B., Dec 2012, In: Diabetes. 61, 12, p. 3270-3279 10 p. Research output: Contribution to journal › Article › peer-review
Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice Patel, M., Wang, X. X., Magomedova, L., John, R., Rasheed, A., Santamaria, H., Wang, W., Tsai, R., Qiu, L., Orellana, A., Advani, A., Levi, M. & Cummins, C. L., Feb 2014, In: Diabetologia. 57, 2, p. 435-446 12 p. Research output: Contribution to journal › Article › peer-review
Beyond the foam cell: The role of LXRs in preventing atherogenesis Rasheed, A. & Cummins, C. L., Aug 7 2018, In: International journal of molecular sciences. 19, 8, 2307. Research output: Contribution to journal › Review article › peer-review
Loss of the Liver X receptors disrupts the balance of hematopoietic populations, with detrimental effects on endothelial progenitor cells Rasheed, A., Tsai, R. & Cummins, C. L., May 15 2018, In: Journal of the American Heart Association. 7, 10, e007787. Research output: Contribution to journal › Article › peer-review
Immune profiling and tracking of two-dimensional transition metal dichalcogenides in cells and tissues Gazzi, A., Fusco, L., Orecchioni, M., Keshavan, S., Shin, Y., Grivel, J. C., Rinchai, D., Ahmed, E. I., Elhanani, O., Furesi, G., Rauner, M., Keren, L., Ley, K., Casiraghi, C., Bedognetti, D., Fadeel, B. & Delogu, L. G., Feb 2024, In: Nano Today. 54, 102084. Research output: Contribution to journal › Article › peer-review
Single Cell High Dimensional Analysis of Human Peripheral Blood Mononuclear Cells Reveals Unique Intermediate Monocyte Subsets Associated with Sex Differences in Coronary Artery Disease Chatterjee, N., Komaravolu, R. K., Durant, C. P., Wu, R., McSkimming, C., Drago, F., Kumar, S., Valentin-Guillama, G., Miller, Y. I., McNamara, C. A., Ley, K., Taylor, A., Alimadadi, A. & Hedrick, C. C., Mar 2024, In: International journal of molecular sciences. 25, 5, 2894. Research output: Contribution to journal › Article › peer-review
NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis Kaufmann, B., Leszczynska, A., Reca, A., Booshehri, L. M., Onyuru, J., Tan, Z. H., Wree, A., Friess, H., Hartmann, D., Papouchado, B., Broderick, L., Hoffman, H. M., Croker, B. A., Zhu, Y. P. & Feldstein, A. E., Jan 1 2024, In: EMBO Reports. 25, 1, p. 455 1 p. Research output: Contribution to journal › Article › peer-review
Examining the interplay between cardiovascular disease and cancer incidence: Data from NHANES III and continuous Makram, O. M., Kunhiraman, H. H., Harris, R. A., Hedrick, C. C., Nasir, K., Weintraub, N. L., Wang, X. & Guha, A., Apr 2024, In: American Heart Journal Plus: Cardiology Research and Practice. 40, 100380. Research output: Contribution to journal › Article › peer-review
NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils Zhu, Y. P., Speir, M., Tan, Z. H., Lee, J. C., Nowell, C. J., Chen, A. A., Amatullah, H., Salinger, A. J., Huang, C. J., Wu, G., Peng, W., Askari, K., Griffis, E., Ghassemian, M., Santini, J., Gerlic, M., Kiosses, W. B., Catz, S. D., Hoffman, H. M. & Greco, K. F. & 6 others, Weller, E., Thompson, P. R., Wong, L. P., Sadreyev, R., Jeffrey, K. L. & Croker, B. A., Dec 2023, In: Science Advances. 9, 51, eadj1397. Research output: Contribution to journal › Article › peer-review
Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy Kaczanowska, S., Murty, T., Alimadadi, A., Contreras, C. F., Duault, C., Subrahmanyam, P. B., Reynolds, W., Gutierrez, N. A., Baskar, R., Wu, C. J., Michor, F., Altreuter, J., Liu, Y., Jhaveri, A., Duong, V., Anbunathan, H., Ong, C., Zhang, H., Moravec, R. & Yu, J. & 24 others, Biswas, R., Van Nostrand, S., Lindsay, J., Pichavant, M., Sotillo, E., Bernstein, D., Carbonell, A., Derdak, J., Klicka-Skeels, J., Segal, J. E., Dombi, E., Harmon, S. A., Turkbey, B., Sahaf, B., Bendall, S., Maecker, H., Highfill, S. L., Stroncek, D., Glod, J., Merchant, M., Hedrick, C. C., Mackall, C. L., Ramakrishna, S. & Kaplan, R. N., Jan 8 2024, In: Cancer Cell. 42, 1, p. 35-51.e8 Research output: Contribution to journal › Article › peer-review
Editorial: Role of innate and adaptive immune cells in the metabolic syndrome Roy, P., Winkels, H., Orecchioni, M., Quesada-Masachs, E. & Riffelmacher, T., 2024, In: Frontiers in Cell and Developmental Biology. 12, 1383642. Research output: Contribution to journal › Editorial › peer-review
Breaking tolerance: the autoimmune aspect of atherosclerosis Khan, A., Roy, P. & Ley, K., Sep 2024, In: Nature Reviews Immunology. 24, 9, p. 670-679 10 p. Research output: Contribution to journal › Article › peer-review
Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality. Rasheed, A., May 13 2015, In: The Journal of biological chemistry. Research output: Contribution to journal › Article › peer-review
Delivery of MicroRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux in Vitro and in Vivo. Rasheed, A., Jun 12 2019, In: ACS Nano. Research output: Contribution to journal › Article › peer-review
RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice Karunakaran, D., Nguyen, M.-A., Geoffrion, M., Vreeken, D., Lister, Z., Cheng, H. S., Otte, N., Essebier, P., Wyatt, H., Kandiah, J. W., Jung, R., Alenghat, F. J., Mompeon, A., Lee, R., Pan, C., Gordon, E., Rasheed, A., Lusis, A. J., Liu, P. & Matic, L. P. & 7 others, Hedin, U., Fish, J. E., Guo, L., Kolodgie, F., Virmani, R., van Gils, J. M. & Rayner, K. J., 2021, In: Circulation. Research output: Contribution to journal › Article › peer-review
The secretome of liver X receptor agonist treated early outgrowth cells decreases atherosclerosis in Ldlr-/- Mice Rasheed, A., Shawky, S., Tsai, R., Jung, R. G., Simard, T., Hibbert, B., Rayner, K. J. & Cummins, C. L., 2019 Research output: Other contribution
Loss of MLKL (Mixed Lineage Kinase Domain-Like Protein) Decreases Necrotic Core but Increases Macrophage Lipid Accumulation in Atherosclerosis. Rasheed, A., Mar 26 2020, In: Arteriosclerosis, thrombosis, and vascular biology. Research output: Contribution to journal › Article › peer-review
Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells during Atherosclerosis Robichaud, S., Rasheed, A., Pietrangelo, A., Doyoung Kim, A., Boucher, D. M., Emerton, C., Vijithakumar, V., Gharibeh, L., Fairman, G., Mak, E., Nguyen, M. A., Geoffrion, M., Wirka, R., Rayner, K. J. & Ouimet, M., Mar 18 2022, In: Circulation research. 130, 6, p. 831-847 17 p. Research output: Contribution to journal › Article › peer-review
The scent of atherosclerosis Rayner, K. J. & Rasheed, A., Jan 14 2022, In: Science. 375, 6577, p. 145-146 2 p. Research output: Contribution to journal › Short survey › peer-review
Dipyridamole and vascular healing following stent implantation Simard, T., Jung, R., Di Santo, P., Labinaz, A., Short, S., Motazedian, P., Dhaliwal, S., Sarma, D., Rasheed, A., Ramirez, F. D., Froeschl, M., Labinaz, M., Holmes, D. R., Alkhouli, M. & Hibbert, B., 2023, In: Frontiers in Cardiovascular Medicine. 10, p. 1130304 Research output: Contribution to journal › Article › peer-review
Niche Regulation of Hematopoiesis: The Environment Is "Micro," but the Influence Is Large Rasheed, A., Jun 2022, In: Arteriosclerosis, thrombosis, and vascular biology. 42, 6, p. 691-699 9 p. Research output: Contribution to journal › Review article › peer-review
Plasminogen Activator Inhibitor-1-Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype Jung, R. G., Duchez, A.-C., Simard, T., Dhaliwal, S., Gillmore, T., Di Santo, P., Labinaz, A., Ramirez, F. D., Rasheed, A., Robichaud, S., Ouimet, M., Short, S., Clifford, C., Xiao, F., Lordkipanidzé, M., Burger, D., Gadde, S., Rayner, K. J. & Hibbert, B., Oct 2022, In: JACC: Basic to Translational Science. 7, 10, p. 985-997 13 p. Research output: Contribution to journal › Article › peer-review
miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages Nguyen, M.-A., Hoang, H.-D., Rasheed, A., Duchez, A.-C., Wyatt, H., Cottee, M. L., Graber, T. E., Susser, L., Robichaud, S., Berber, İ., Geoffrion, M., Ouimet, M., Kazan, H., Maegdefessel, L., Mulvihill, E. E., Alain, T. & Rayner, K. J., Jun 24 2022, In: Circulation research. 131, 1, p. 42-58 17 p. Research output: Contribution to journal › Article › peer-review
Correcting for sparsity and non-independence in glycomic data through a systems biology framework Chiang, A., Jul 5 2019 Research output: Other contribution
Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multiomics integration Chiang, A., Sep 3 2020 Research output: Other contribution
Combating viral contaminants in CHO cells by engineering innate immunity Chiang, A. W. T., Li, S., Kellman, B. P., Chattopadhyay, G., Zhang, Y., Kuo, C.-C., Gutierrez, J. M., Ghazi, F., Schmeisser, H., Ménard, P., Bjørn, S. P., Voldborg, B. G., Rosenberg, A. S., Puig, M. & Lewis, N. E., 2019, In: Scientific reports. Research output: Contribution to journal › Article › peer-review
Increasing consensus of context-specific metabolic models by integrating data-inferred cell functions Richelle, A., Chiang, A. W. T., Kuo, C.-C. & Lewis, N. E., 2019, In: PLoS Computational Biology. Research output: Contribution to journal › Article › peer-review
Program and Abstracts for 2018 Annual Meeting of the Society for Glycobiology Chiang, A., 2018, In: Glycobiology. Research output: Contribution to journal › Article › peer-review
The emerging role of systems biology for engineering protein production in CHO cells Kuo, C.-C., Chiang, A. W., Shamie, I., Samoudi, M., Gutierrez, J. M. & Lewis, N. E., 2018, In: Current Opinion in Biotechnology. Research output: Contribution to journal › Article › peer-review
Modulating carbohydrate–protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology Chiang, A. W., Li, S., Spahn, P. N., Richelle, A., Kuo, C.-C., Samoudi, M. & Lewis, N. E., 2016, In: Current Opinion in Structural Biology. Research output: Contribution to journal › Article › peer-review
Identification of Entry Factors Involved in Hepatitis C Virus Infection Based on Host-Mimicking Short Linear Motifs Chiang, A. W. T., Wu, W. Y. L., Wang, T. & Hwang, M.-J., 2017, In: PLoS Computational Biology. Research output: Contribution to journal › Article › peer-review
Proteins with Highly Evolvable Domain Architectures Are Nonessential but Highly Retained Hsu, C.-H., Chiang, A. W. T., Hwang, M.-J. & Liao, B.-Y., 2016, In: Molecular Biology and Evolution. Research output: Contribution to journal › Article › peer-review
A proteome view of structural, functional, and taxonomic characteristics of major protein domain clusters Sun, C.-T., Chiang, A. W. T. & Hwang, M.-J., 2017, In: Scientific reports. Research output: Contribution to journal › Article › peer-review
Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters Chiang, A. W. T., Liu, W.-C., Charusanti, P. & Hwang, M.-J., 2014, In: BMC Systems Biology. Research output: Contribution to journal › Article › peer-review
A computational pipeline for identifying kinetic motifs to aid in the design and improvement of synthetic gene circuits Chiang, A. W. T. & Hwang, M.-J., 2013, In: BMC Bioinformatics. Research output: Contribution to journal › Article › peer-review
Partitioning the human transcriptome using Hkera, a novel classifier of housekeeping and tissue-specific genes Chiang, A. W. T., Shaw, G. T. W. & Hwang, M.-J., 2013, In: PloS one. Research output: Contribution to journal › Article › peer-review
Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype Chiang, A., Nov 2020, In: Gastroenterology. Research output: Contribution to journal › Article › peer-review
Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders Chiang, A., May 1 2021, In: Journal of Pediatric Gastroenterology and Nutrition. 72, 5, p. 718-722 5 p. Research output: Contribution to journal › Article › peer-review
The human milk oligosaccharide 3’sialyllactose promotes inflammation resolution and reduces atherosclerosis development. Pessentheiner, A., Spann, N., Collins, C., Ramms, B., Chiang, A., Wang, Y., Quach, A., Booshehri, L., Hammond, A., Tognaccini, C., Latasiewicz, J., Witztum, J. L., Hoffman, H., Lewis, N., Glass, C., Bode, L. & Gordts, P., Aug 2021, In: Atherosclerosis. Research output: Contribution to journal › Article › peer-review
ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis Weiss, R. J., Spahn, P. N., Toledo, A. G., Chiang, A. W. T., Kellman, B. P., Li, J., Benner, C., Glass, C. K., Gordts, P. L. S. M., Lewis, N. E. & Esko, J. D., 2020, In: Proceedings of the National Academy of Sciences of the United States of America. Research output: Contribution to journal › Article › peer-review

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Immunology Research

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