Scott A. Barman, PhD
706-721-6352 |
Research & Education Building,CB 3626 Officephone icon: 706-721-6352 Members of the Lab |
My laboratory is dedicated to investigating Galectin-3 (Gal-3) and PDZ-binding kinase (PBK) inhibition as potential therapeutic targets for pulmonary vascular disease by investigating the role of Gal-3 and PBK signaling in pulmonary vascular remodeling and fibrosis in PAH using an integrated approach of multiple animal models of PAH, cellular studies, pharmacological and genetic approaches (including KO rat models), as well asin vivoandin vitromeasurements of pulmonary arterial and right ventricular function.
BS Muhlenberg College, Allentown, Pennsylvania
PhD University of North Dakota, Grand Forks, ND
Postdoctoral Training University of South Alabama, Mobile, Alabama
Professor (tenured), Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University
Vice Chair of Education, Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University
Assistant Dean of Admissions, Medical College of Georgia at Augusta University
Editorial Board Member, The Open Nitric Oxide Journal
Respiratory Integrative Biology and Translational Research (RIBT) Study Section – Standing Member
Dean's List, Muhlenberg College
Graduate Research Assistantship, Department of Physiology, University of North Dakota
Graduate Research Assistantship, Department of Physiology, University of North Dakota North Dakota State Board of Higher Education Scholarship
Graduate Student Award for Outstanding Scientific Research-Sigma Xi Research Society, University of North Dakota Chapter
Parker B. Francis Fellowship
American Heart Association Fellowship
NRSA Award
Outstanding Young Faculty Member Award (Basic Sciences) - Medical College of Georgia
Department of Pharmacology & Toxicology Teaching Award, Medical College of Georgia
Outstanding Leadership and Service Award – General Faculty Assembly, Medical Coll. of Georgia
School of Graduate Studies Distinguished Service Award, Medical College of Georgia
Outstanding Service Award – Co-Parliamentarian of Academic Council, Medical Coll. of Georgia
Fellow of American Heart Association (FAHA)
Travel Award – Pittsburgh International Lung Conference
Barman SA, Chen F, Su Y, Dimitropoulou C, Wang Y, Catravas JD, Han W, Orfi L, Szantai-Kis C, Keri G, Szabadkai I, Barabutis N, Rafikova O, Rafikov R, Black SM, Jonigk D, Giannis A, Asmis R, Stepp DW, Ramesh G, Fulton DJ. NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.Arterioscler Thromb Vasc Biol2014 Aug;34(8):1704-15. doi: 10.1161/ATVBAHA.114.303848. PMID: 24947524
Chen F, LiX, Haigh H; Zhou, J; Stepp D, Weintraub N,Barman S, and Fulton D. Inhibition of Histone Deacetylase Reduces Transcription of NADPH Oxidases and ROS production and Ameliorates Pulmonary Arterial Hypertension.Free Rad Biol Med2016 Oct;99:167-178 PMID: 27498117
Barman SA, and Fulton D. Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension.Adv Exp Med Biol967:1-11, 2017. PMID: 29047077
Fulton DJR, Li X, Bordan Z, Haigh S, Bentley A, Chen F,Barman SA. Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension.Antioxidants(Basel) 6(3), 2017. PMID: 28684719
Barman SA, Chen F, Li X, Haigh S, Stepp DW, Kondrikov D, Bordan Z, Traber P, Jonigk D, Su Y and Fulton DJR. Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Arterial HypertensionAm J Resp Crit Care Med1; 197(11):1488-1492, 2018. PMID: 29365276
Barman SA,Li X,HaighS, KondrikovD, MahboubiK,BordanZ, Stepp DW, ZhouJ, WangY, WeintraubDS, TraberP, SniderW, JonigkD, SullivanJ, CrislipGR¸ButcherJT, ThompsonJ, SuY, Chen F, and Fulton DJR.Galectin-3 is Expressed in Vascular Smooth Muscle Cells and Promotes Pulmonary Hypertension through changes in Proliferation, Apoptosis and Fibrosis.Am J Physiol - Lung Cell Physiol316: L784-797, 2019. PMID: 30724100
Fulton DJR, Li X, Bordan Z Wang Y, Mahboubi K, Rudic RD, Haigh S, Chen F, andBarman SA. Galectin-3: A Harbinger of Reactive Oxygen Species, Fibrosis and Inflammation in PAH.Antioxidants & Redox Signaling31:1053-1069, 2019. PMID: 30767565
Kovacs L, Cao Y, Han W, Meadows, L, Kovacs-Kasa A, Kondrikov D, Verin AD,Barman SA, Dong Z, Huo Y, and Su Y. PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.Am J Resp Crit Care Med200:617-627, 2019. PMID: 30817168
Cao Y, Zhang X, Wang L, Yang Q, Ma Q, Xu J, Wang J, Kovacs L, Ayon RJ, Liu Z, Zhang M, Zhou Y, Zeng X, Xu Y, Wang Y, Fulton DJ, Weintraub NL, Lucas R, Dong Z, Yuan JX, Sullivan JC, Meadows L,Barman SA, Wu C, Quan J, Hong M, Su Y, Huo Y. PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension.Proc Natl Acad Sci U S.A.116:13394-13403, 2019. PMID: 31213542