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Research & Education Building,CB 3528Officephone icon: 706-721-0999Labphone icon: 706-721-9860Members of the Lab |
Intracellular trafficking, signal regulation and patho-physiological functions of G protein-coupled receptors and G proteins.
1995 -1998 Post-Doctoral Fellowship Medical University of South Carolina
1992 Ph.D in Physiology Peking Union Medical College and Chinese Academy of Medical Sciences, China
1988 M.S. in Biochemistry Xuzhou Medical College, China
1983 B.S. in Biochemistry Beijing Normal University, China
2011 - Present Professor (with Tenure), Department of Pharmacology and Toxicology, MCG, Augusta University, Augusta, GA.
2001 - 2011 Assistant/Associate Professor, Department of Pharmacology and Experimental Therapeutics, Louisiana State
University Health Sciences Center New Orleans, LA.
1999 - 2001 Assistant Professor, Department of Internal Medicine, University of Cincinnati, OH
Frontiers in Bioscience – Landmark
Frontiers in Neuroscience
iScience
PLoS ONE
Khater M, Bryant CN andWu G.Gbgtranslocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.J Biol Chem296:100805 (2021)
Khater M, Wei Z, Xu X, Huang W, Lokeshwar BL, Lambert NA and Wu G. Gprotein bg translocation to the Golgi apparatus activates MAPK via PI3Kg.J Biol Chem296:100325 (2021)
Wei Z, Xu X, Fang Y,Khater M,NaughtonSX,Hu G,Terry AV Jr.and Wu G. Rab43 GTPase directs post-synaptic trafficking and neuron-specific sorting of G protein-coupled receptors.J Biol Chem296:100517 (2021)
Fang Y, Jiang Q, Li S, Zhu H, Xu R, Song N, Ding X, Liu J, Chen M, Song M, Ding J, Lu M, Wu G and Hu G. Opposing functions of β-arrestin1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3.Cell Death Differ28(6):1822-1836 (2021)
Zhang M, Xu X, Li C, Huang W, Xu N, and Wu G. A naturally occurring splice variant of GGA1 inhibits the anterograde post-Golgi traffic of a2B-adrenergic receptor.Sci Rep9:10378 (2019)
Wei Z, Zhang M, Li C, Huang W, Fan Y, Guo J, Khater M, Fukuda M, Dong Z, Hu G andWu G. Specific TBC domain-containing proteins control the ER-Golgi-plasma membrane trafficking of GPCRs.Cell Rep28(2):554-566 (2019)
Li ZW, Sun B, Gong T, Guo S, Zhang J, Wang J, Sugawara A, Jiang M, Yan J, Gurary A, Zheng X, Gao B, Xiao SY, Chen W, Ma C, Farrar C, Zhu C, Chan OTM, Xin C, Winnicki A, Winnicki J, Tang M, Park R, Winnicki M, Diener K, Wang Z, Liu Q, Chu CH, Arter ZL, Yue P, Alpert L, Hui GS, Fei P, Turkson J, Yang W, Wu G, Tao A, Ramos JW, Moisyadi S, Holcombe RF, Jia W, Birnbaumer L, Zhou X and Chu WM. GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and downregulating expression of GNAI.Gastroenterology156(8):2297-2312 (2019)
Li C, Wei Z, Fan Y, Huang W, Su Y, Li H, Dong Z, Fukuda M, Khater M and Wu G. The GTPase Rab43 controls the anterograde ER-Golgi trafficking and sorting of GPCRs.Cell Rep21(4):1089-1101 (2017)
Zhang M, Huang W, Gao J, Terry AV Jr and Wu G. Regulation of α2B-adrenergic receptor cell surface transport by GGA1 and GGA2.Sci Rep6:37921(2016)
Zhang M, Davis JE, Li C, Gao J, Huang W, Lambert NA, Terry AV Jr.and Wu G. GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export.Mol Cell Biol36(7):1152-1163 (2016)