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  • Zsolt Bagi

Zsolt Bagi

Dr. Zsolt Bagi

Professor

Phone:(706) 721-8819
Fax:(706) 721-7299
Email:zbagi@augusta.edu
Office:CA-3133
Lab:CA-3132A

Education & Training

General Semmelweis University of Budap,Biomedical Sciences, PhD, 2004

Semmelweis University of Budap,Medicine, MD, 2000

Academic Appointments

2001-2010|Assistant Professor, New York Medical College
2010-2012|Intermediate Research Fellow, British Heart Foundation Center of Research Excellence at University of Oxford
2011-2013|Senior Research Fellow, Somerville College, Oxford University
2013 - 2019|Associate Professor, Augusta University
2019|Professor, Deparment of Physiology, Medical College of Georgia, Augusta University

Jump to:Research InterestsAwards & HonorsRelated LinksAbout Dr. Bagi's Research Lab

Dr. Bagi's Faculty Profile

Link to Dr. Brands on PubMed

LAB PERSONNEL

Liwei LangLiwei Lang, PhD
Assistant Research Scientist

Marta BagineMarta Bagine Balogh
Research Associate

Vadym Buncha

Vadym Buncha
Graduate Student

KA Fopiano

Katherine Fopiano
Graduate Student

Research Interests

Coronary microvascular disease in patients with diabetes mellitus and diastolic heart failure.

Publication

Dynamic Neuro-Glial-Vascular Responses in a Mouse Model of Vascular Cognitive Impairment

Kim, K. J., Patterson, R. E., Diaz, J. R., O’Herron, P., Bush, W., Althammer, F., Stern, J. E., Brands, M. W., Bagi, Z.& Filosa, J. A., Dec 2024, In:Neuroglia. 5, 4, p. 505-521 17 p.

Research output:Contribution to journal›Article›peer-review

Sex-specific molecular drivers of cardiac fibrosis in aging hearts

Fopiano, K. A., Balogh, M. B., Patel, V. S., Ilatovskaya, D. V.& Bagi, Z., 2025, (Accepted/In press) In:GeroScience.

Research output:Contribution to journal›Article›peer-review

Endothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling

Buncha, V., Lang, L., Fopiano, K. A., Ilatovskaya, D. V., Kapuku, G., Verin, A. D.& Bagi, Z., Feb 2025, In:American Journal of Physiology - Heart and Circulatory Physiology. 328, 2, p. H283-H293

Research output:Contribution to journal›Article›peer-review

PDE9A Inhibition Improves Coronary Microvascular Rarefaction and Left Ventricular Diastolic Dysfunction in the ZSF1 Rat Model of HFpEF

Fopiano, K. A., Zhazykbayeva, S., El-Battrawy, I., Buncha, V., Pearson, W. M., Hardell, D. J., Lang, L., Hamdani, N. & Bagi, Z., Nov 2024, In:Microcirculation. 31, 8, e12888.

Research output:Contribution to journal›Article›peer-review

Altered copper transport in oxidative stress-dependent brain endothelial barrier dysfunction associated with Alzheimer's disease

Hossain, M. S., Das, A., Rafiq, A. M., Deák, F., Bagi, Z., Outlaw, R., Sudhahar, V., Yamamoto, M., Kaplan, J. H., Ushio-Fukai, M.& Fukai, T., Dec 2024, In:Vascular Pharmacology. 157, 107433.

Research output:Contribution to journal›Article›peer-review

Phosphodiesterase 9A inhibition improves aging-related increase in pulmonary vascular resistance in mice

Buncha, V., Fopiano, K. A., Lang, L., Ilatovskaya, D. V., Verin, A.& Bagi, Z., Oct 2024, In:GeroScience. 46, 5, p. 5191-5202 12 p.

Research output:Contribution to journal›Article›peer-review

AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice

Zhou, H., Fick, K., Patel, V., Hilton, L. R., Kim, H. W., Bagi, Z., Weintraub, N. L.& Chen, W., Jul 2024, In:American Journal of Physiology - Endocrinology and Metabolism. 327, 1, p. E69-E80

Research output:Contribution to journal›Article›peer-review

Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology

Patil, R. S., Maloney, M. E., Lucas, R., Fulton, D. J. R., Patel, V., Bagi, Z., Kovacs-Kasa, A., Kovacs, L., Su, Y. & Verin, A. D., Feb 2024, In:Biomolecules. 14, 2, 140.

Research output:Contribution to journal›Review article›peer-review

The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer’s disease

Tian, Y., Fopiano, K. A., Buncha, V., Lang, L., Suggs, H. A., Wang, R., Rudic, R. D., Filosa, J. A.& Bagi, Z., 2023, In:Frontiers in Molecular Neuroscience. 16, 1125932.

Research output:Contribution to journal›Article›peer-review

Microvascular contributions to white matter injury in Alzheimer’s disease

Bagi, Z., Sherman, L. S. & Back, S. A., 2023, In:Aging. 15, 16, p. 7860-7862 3 p.

Research output:Contribution to journal›Editorial›peer-review

Mice with endothelial cell-selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunction

Buncha, V., Fopiano, K. A., Lang, L., Williams, C., Horuzsko, A., Filosa, J. A., Kapuku, G.& Bagi, Z., Mar 2023, In:Physiological reports. 11, 6, e15643.

Research output:Contribution to journal›Article›peer-review

Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine Brain

Adeniyi, P. A., Fopiano, K. A., Banine, F., Garcia, M., Gong, X., Keene, C. D., Sherman, L. S., Bagi, Z.& Back, S. A., 2022, In:ASN Neuro. 14

Research output:Contribution to journal›Article›peer-review

Deficiency of Myeloid Pfkfb3 Protects Mice From Lung Edema and Cardiac Dysfunction in LPS-Induced Endotoxemia

Xu, J., Wang, L., Yang, Q., Ma, Q., Zhou, Y., Cai, Y., Mao, X., Da, Q., Lu, T., Su, Y., Bagi, Z., Lucas, R., Liu, Z., Hong, M., Ouyang, K. & Jiao, K., 2021, In:Frontiers in Cardiovascular Medicine. 8, p. 745810745810.

Research output:Contribution to journal›Article›peer-review

Association of cerebral microvascular dysfunction and white matter injury in Alzheimer’s disease

Bagi, Z., Kroenke, C. D., Fopiano, K. A., Tian, Y., Filosa, J. A., Sherman, L. S., Larson, E. B., Keene, C. D., Degener O’Brien, K., Adeniyi, P. A. & Back, S. A., Aug 2022, In:GeroScience. 44, 4, p. 1-14 14 p.

Research output:Contribution to journal›Article›peer-review

Coronary Microvascular Dysfunction and Heart Failure with Preserved Ejection Fraction-implications for Chronic Inflammatory Mechanisms

Fopiano, K. A., Jalnapurkar, S., Davila, A. C., Arora, V.& Bagi, Z., Mar 2022, In:Current Cardiology Reviews. 18, 2, p. 6-14 9 p., e310821195986.

Research output:Contribution to journal›Article›peer-review

Role of Caveolae in the Development of Microvascular Dysfunction and Hyperglycemia in Type 2 Diabetes

Tian, Y., Fopiano, K. A., Patel, V. S., Feher, A. & Bagi, Z., Feb 18 2022, In:Frontiers in Physiology. 13, 825018.

Research output:Contribution to journal›Article›peer-review

GDP in Dialysis Associates with Peritoneal Vascular Remodeling in Kidney Disease

Han, Q., Orr, Z. J., DeSouza, G. K., Bagi, Z.& Rudic, R. D., Aug 20 2021, In:Circulation research. 129, 5, p. 527-529 3 p.

Research output:Contribution to journal›Review article›peer-review

Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17

Tian, Y., Fopiano, K. A., Buncha, V., Lang, L., Rudic, R. D., Filosa, J. A., Dou, H. & Bagi, Z., Feb 2022, In:GeroScience. 44, 1, p. 349-369 21 p.

Research output:Contribution to journal›Article›peer-review

Review: Circadian clocks and rhythms in the vascular tree

Han, Q., Bagi, Z.& Daniel Rudic, R., Aug 2021, In:Current Opinion in Pharmacology. 59, p. 52-60 9 p.

Research output:Contribution to journal›Review article›peer-review

Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation

Kolijn, D., Pabel, S., Tian, Y., Lódi, M., Herwig, M., Carrizzo, A., Zhazykbayeva, S., Kovács, Á., Fülöp, G., Falcão-Pires, I., Reusch, P. H., Linthout, S. V., Papp, Z., Van Heerebeek, L., Vecchione, C., Maier, L. S., Ciccarelli, M., Tschöpe, C., Mügge, A. & Bagi, Z. & 2 others, Sossalla, S. & Hamdani, N., Feb 1 2021, In:Cardiovascular Research. 117, 2, p. 495-507 13 p.

Research output:Contribution to journal›Article›peer-review

A Novel Subset of CD95+Pro-Inflammatory Macrophages Overcome miR155 Deficiency and May Serve as a Switch From Metabolically Healthy Obesity to Metabolically Unhealthy Obesity

Johnson, C., Drummer IV, C., Shan, H., Shao, Y., Sun, Y., Lu, Y., Saaoud, F., Xu, K., Nanayakkara, G., Fang, P., Bagi, Z., Jiang, X., Choi, E. T., Wang, H. & Yang, X., Jan 7 2021, In:Frontiers in immunology. 11, 619951.

Research output:Contribution to journal›Article›peer-review

Effects of race, cardiac mass, and cardiac load on myocardial function trajectories from childhood to young adulthood: The augusta heart study

Kapuku, G., Howie, M., Ghosh, S., Doshi, V., Bykhovsky, M., Ange, B., Halbert, J. D., Robinson, V., Bagi, Z., Harshfield, G. & George, V., 2021, In:Journal of the American Heart Association. 10, 3, p. 1-8 8 p., e015612.

Research output:Contribution to journal›Article›peer-review

Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass

Hao, G., Halbert, J., Su, S., Bagi, Z., Robinson, V., Thayer, J., Harshfield, G. & Kapuku, G., 2021, In:Acta Cardiologica. 76, 10, p. 1117-1123 7 p.

Research output:Contribution to journal›Article›peer-review

Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders

Yang, Q., Ma, Q., Xu, J., Liu, Z., Zou, J., Shen, J., Zhou, Y., Da, Q., Mao, X., Lu, S., Fulton, D. J., Weintraub, N. L., Bagi, Z., Hong, M. & Huo, Y., 2020, In:Frontiers in Cell and Developmental Biology. 8, p. 611354611354.

Research output:Contribution to journal›Article›peer-review

Vasculo-Neuronal Coupling and Neurovascular Coupling at the Neurovascular Unit: Impact of Hypertension

Presa, J. L., Saravia, F., Bagi, Z.& Filosa, J. A., Sep 25 2020, In:Frontiers in Physiology. 11, 584135.

Research output:Contribution to journal›Review article›peer-review

Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction

Davila, A., Tian, Y., Czikora, I., S. Weissman, A., Weinand, N., Dong, G., Xu, J., Li, J., Su, H., Kapuku, G., Huo, Y. & Bagi, Z., Aug 1 2020, In:Microcirculation. 27, 6, e12624.

Research output:Contribution to journal›Article›peer-review

Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance

Xu, J., Yang, Q., Zhang, X., Liu, Z., Cao, Y., Wang, L., Zhou, Y., Zeng, X., Ma, Q., Xu, Y., Wang, Y., Huang, L., Han, Z., Wang, T., Stepp, D., Bagi, Z., Wu, C., Hong, M. & Huo, Y., Aug 2019, In:Journal of Endocrinology. 242, 2, p. 159-172 14 p.

Research output:Contribution to journal›Article›peer-review

Adenosine kinase inhibition augments conducted vasodilation and prevents left ventricle diastolic dysfunction in heart failure with preserved ejection fraction

Davila, A., Tian, Y., Czikora, I., Li, J., Su, H., Huo, Y., Patel, V., Robinson, V., Kapuku, G., Weintraub, N.& Bagi, Z., Aug 1 2019, In:Circulation: Heart Failure. 12, 8, e005762.

Research output:Contribution to journal›Article›peer-review

Extracellular vesicle integrins act as a nexus for platelet adhesion in cerebral microvessels

Bagi, Z., Couch, Y., Broskova, Z., Perez-Balderas, F., Yeo, T., Davis, S., Fischer, R., Sibson, N. R., Davis, B. G. & Anthony, D. C., Dec 1 2019, In:Scientific reports. 9, 1, 15847.

Research output:Contribution to journal›Article›peer-review

Akt2 (protein kinase B beta) stabilizes ATP7A, a copper transporter for extracellular superoxide dismutase, in vascular smooth muscle: Novel mechanism to limit endothelial dysfunction in type 2 diabetes mellitus

Sudhahar, V., Okur, M. N., Bagi, Z., O'Bryan, J. P., Hay, N., Makino, A., Patel, V. S., Phillips, S. A., Stepp, D., Ushio-Fukai, M.& Fukai, T., 2018, In:Arteriosclerosis, thrombosis, and vascular biology. 38, 3, p. 529-541 13 p.

Research output:Contribution to journal›Article›peer-review

View All Publications.

Awards & Honors

Bristol-Myers Squibb Young Investigator Award of the American Physiological Society

  • 2008

ATVB Merit Award of the American Heart Association

  • 2007

Van Leeuwenhoek Distinctive Travel Award of the European Society for Microcirculation

  • 2004

Zweifach Student Award of the American Microcirculatory Society

  • 2004

Caroline tum Suden/Frances A. Hellenbrandt Award, American Physiological Society

  • 2003

Related Links

  • Higher blood pressure over life span increases congestive heart failure risk in Black people (EurekAlert!)
  • Sticky situation inside blood vessels can worsen stroke damage (EurekAlert!)
  • New target found for disease of the heart's smallest blood vessels (ScienceDaily)
  • Researchers find new target for disease of the heart's smallest blood vessels (News Medical Life Sciences)
  • New target found for disease of the heart's smallest blood vessels (EurekAlert!)
  • Scientists learning more about how poor sleep habits can translate to stiff blood vessels (EurekAlert!)
  • Age and obesity conspire to damage the tiny blood vessels that feed the heart, causing heart failure (JagWire)

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