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Research & Education Building,CB 3616 Members of the Lab |
Studies the rules and mechanisms governing information transfer between neurons, which are essential processes to provide instructions for locomotion and motor coordination. Research utilizes CRISPR/Cas9 gene editing tools in tandem with optical imaging strategies to interrogate the molecular architecture underlying neuronal signal decoding logic.
2014-2020 Postdoc The Scripps Research Institute
2014 PhD in Medicinal Chemistry The University of Toledo
2009 BS in Medicinal & Biological Chemistry The University of Toledo
2020 - Present Assistant Professor, Medical College of Georgia, Department of Pharmacology and Toxicology
2020 - Present Assistant Professor, The Graduate School
2020 - The Bow Foundation Postdoctoral Fellowship
2017 - Great Lakes GPCR Retreat Poster Award 1st Place
2016 - Ruth L. Kirschstein Postdoctoral Individual National Research Service Award
Sloan DC, Cryan CE,Muntean BS. Multiple potassium channel tetramerization domain (KCTD) family members interact with Gβγ, with effects on cAMP signaling. J Biol Chem . 2023 Mar;299(3):102924.
Muntean BS, Marwari S, Li X, Sloan DC, Young BD, Wohlschlegel JA, Martemyanov KA. Members of the KCTD family are major regulators of cAMP signaling. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1).
Muntean BS, Masuho I, Dao M, Sutton LP, Zucca S, Iwamoto H, Patil DN, Wang D, Birnbaumer L, Blakely RD, Grill B, Martemyanov KA. Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders. Cell Rep. 2021 Feb 2;34(5):108718.
Masuho I, Balaji S, Muntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA. A global map of G protein signaling regulation by RGS proteins. Cell. 2020 Sep 24;S0092-8674(20)31140-5.
Muntean BS. Dorsal striatum dynamically incorporates velocity adjustments during locomotion. J Neurosci. 2020 Sep 2;40(36):6822-6824.
Muntean BS, Dao MT, Martemyanov KA. Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling. Cell Rep. 2019 Oct 22;29(4):946-960.e2.
Sutton LP, Muntean BS, Ostrovskaya O, Zucca S, Dao M, Orlandi C, Song C, Xie K, Martemyanov KA. NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control. PLoS Biol. 2019 Oct 10;17(10):e3000477.
Muntean BS, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA. Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Cell Rep. 2018 Jan 2;22(1):255-268.
Muntean BS, Martemyanov KA. Association with the Plasma Membrane is Sufficient for Potentiating Catalytic Activity of Regulators of G protein Signaling (RGS) Proteins of the R7 subfamily. J Biol Chem. 2016 Mar 25;291(13):7195-204.
AbouAlaiwi WA, Muntean BS, Ratnam S, Joe B, Liu L, Booth RL, Rodriguez I, Herbert BS, Bacallao RL, Fruttiger M, Mak TW, Zhou J, Nauli SM. Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation. 2014 Feb 11;129(6):660-72.
Muntean BS, Jin X, Williams FE, Nauli SM. Primary cilium regulates CaV1.2 expression through Wnt signaling. J Cell Physiol. 2014 Dec;229(12):1926-34.